When you’re suffering from a cold or flu, finding the right medication can make a huge difference in how you feel. At Murrays Pharmacy, we understand that navigating the vast range of cold and flu tablets available can be overwhelming. Different products target different symptoms, and not all medications are equally effective for every individual. In this guide, we’ll break down the most effective over-the-counter cold and flu tablets and explain how they work, helping you choose the right treatment for fast relief.
Understanding Cold and Flu Symptoms
Before selecting a medication, it’s important to recognise the symptoms you’re experiencing. The common cold and flu share several symptoms, but flu tends to be more severe. Typical symptoms include:
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- – Sore throat
- – Runny or blocked nose
- – Sneezing
- – Cough
- – Fever
- – Fatigue
- – Muscle aches
Cold symptoms usually develop gradually, while flu symptoms can appear suddenly and be accompanied by high fever and body aches. Identifying your symptoms will help you choose the most suitable cold and flu tablets.
The Most Effective Cold and Flu Tablets
Over-the-counter cold and flu tablets often contain a combination of active ingredients to target multiple symptoms. Here’s a breakdown of what works best and why.
1. Paracetamol-Based Cold and Flu Tablets
How They Work: Paracetamol is a widely used pain reliever and fever reducer. It helps alleviate headaches, muscle pain, and fever associated with colds and flu.
Best For:
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- – Reducing fever
- – Relieving body aches and mild headaches
- – Easing mild sore throat discomfort
Popular Brands:
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- – Lemsip Max All in One
- – Panadol Cold & Flu Relief
Does It Work? Yes, paracetamol is highly effective for managing pain and fever. However, it does not relieve nasal congestion or a runny nose.
2. Ibuprofen-Based Cold and Flu Tablets
How They Work: Ibuprofen is an anti-inflammatory medication that reduces swelling, pain, and fever. It is useful for treating flu-related aches and a sore throat.
Best For:
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- – Reducing inflammation and body pain
- – Lowering fever
- – Relieving sinus pressure headaches
Popular Brands:
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- – Nurofen Cold & Flu
- – Sudafed Sinus Pressure & Pain
Does It Work? Yes, ibuprofen is effective for fever and body aches, but it does not provide relief from congestion or coughing.
3. Decongestant Cold and Flu Tablets
How They Work: Decongestants such as phenylephrine or pseudoephedrine work by narrowing blood vessels in the nasal passages, reducing swelling and clearing congestion.
Best For:
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- – Relieving blocked nose and sinus congestion
- – Reducing swelling in nasal passages
- – Easing pressure headaches caused by congestion
Popular Brands:
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- – Sudafed Blocked Nose Relief
- – Day & Night Nurse
Does It Work? Yes, decongestants are very effective at clearing nasal congestion. However, they should not be used for more than a few days, as overuse can lead to rebound congestion.
4. Combination Cold and Flu Tablets
How They Work: These tablets contain a mix of paracetamol, decongestants, and sometimes caffeine, offering multi-symptom relief.
Best For:
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- – Relieving multiple symptoms at once (e.g., fever, congestion, aches)
- – Providing daytime energy boosts (with caffeine) and nighttime relief
Popular Brands:
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- – Lemsip Max Day & Night Cold & Flu Relief
- – Beechams All in One
Does It Work? Yes, combination tablets are highly effective for tackling multiple cold and flu symptoms at once, making them a convenient option.
What Doesn’t Work as Well?
While some cold and flu tablets are highly effective, others may not provide the relief you expect. Here are some treatments that may not work as well:
1. Vitamin C Tablets for Cold and Flu Treatment
There is limited evidence that vitamin C prevents colds or speeds up recovery, though it may slightly reduce symptom duration.
2. Antihistamine-Only Tablets for Cold Relief
Antihistamines can help with a runny nose but are not effective against nasal congestion or fever in flu cases.
3. Antibiotics for Colds and Flu
Colds and flu are caused by viruses, not bacteria, meaning antibiotics will not be effective unless a secondary bacterial infection develops.
Choosing the Right Cold and Flu Tablets
To select the best cold and flu tablets, match your symptoms to the most effective active ingredients:
For fever and aches: Paracetamol or ibuprofen-based tablets
For congestion: Decongestants like pseudoephedrine
For multiple symptoms: Combination tablets
For sinus headaches: Ibuprofen and decongestant combinations
When to Seek Medical Advice
Most colds and mild flu cases resolve within a week. However, seek medical attention if you experience persistent high fever (above 39°C), difficulty breathing or chest pain, or severe sinus pain and swelling. You should also seek support if your symptoms lasting more than 10 days.
You can also reach out to our team to take proactive steps in protecting your health by booking your flu vaccine. Stay ahead of seasonal illnesses and ensure you’re protected before symptoms strike.
Speedy Up Your Recovery
Finding the right cold and flu tablets can help ease your symptoms and speed up recovery. At Murrays Pharmacy, we stock a wide range of over-the-counter treatments tailored to your symptoms. If you are unsure which tablets to take, our team is happy to provide guidance on the best options for you.
For personalised advice on managing cold and flu symptoms, contact Murrays Pharmacy or speak to one of our friendly pharmacists today.
Alternatively, book a flu vaccine today and protect yourself against this potentially serious illness:

This blog was written on behalf of Murrays Pharmacy by Pharmacy Mentor.